Medical Service Bureau was established in 1937 by a group of physicians from the Medical Society of Sedgwick County who wanted to provide a social service agency through which low income persons could arrange for their medical needs, according to their ability to pay for them.  The process started on Friday, January 24, 1936, when an article appeared in the Wichita Beacon newspaper titled “Medical Help Will Be Given to Poor Folks”, “Community Chest Planning New System of Aid for Needy”. The article went on to report that the health division of the social planning committee of the Community Chest (now known as United Way of the Plains) was mapping out a campaign of caring for families suffering from illness, but who are unable to pay for the services of a physician or to buy medicine. It was suggested that a Medical Service Bureau be established.

Over the years the Medical Service Bureau has maintained its relationship with the Medical Society of Sedgwick County and the United Way of the Plains.The Medical Service Bureau was established as a local service agency and has never affiliated with any national organization. The Medical Service Bureau incorporated as a non-profit 501 (c)(3) on July 26, 1978.